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Extended titration, where you stay at a lower dose for longer before increasing, is the evidence-based approach to managing GI side effects and may solve your problem without any experimental modifications

It felt nerve-wracking at first, but by the time the first dose was done, it was easier than expected

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Johnson notes that the ripple effects are already spreading outside healthcare, with companies reshaping portfolios and expanding into products tailored to GLP-1 users in food and nutrition

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It's worth noting that GLP-1 receptor agonists rarely cause hypoglycaemia unless combined with insulin or sulfonylureas, so this is an unlikely cause of headaches for most patients