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Experimental observations also show delayed gastric emptying consistent with GLP-1 receptor signaling, although this effect may diminish over extended observation periods in some research models

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The number on the scale may be acting like the 'canary in the coal mine.' It may be telling us about swallowing issues, loss of smell, gastrointestinal dysfunction, frailty, muscle loss, medication interactions or changes in cognition long before these problems become obvious