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Description
Maximal glycaemic effects typically occur over 3 to 6 months following dose titration, with HbA1c improvements assessed at approximately 3 months after starting treatment

GLP-1s are cornerstone metabolic therapies, most effective when combined with lifestyle interventions and complementary geroprotective strategies that support vascular health, mitochondrial function, and dementia prevention

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This triple agonism creates synergistic effects across central and peripheral pathways, influencing appetite regulation, energy expenditure, glucose homeostasis, lipid metabolism, and substrate utilization

It is crucial to recognise that pre-existing gastroparesis or diabetic autonomic neuropathy may complicate the clinical picture

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