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When the fat compartments shrink, the overlying skin loses its firmness, resulting in a deflated appearance and skin laxity

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In one study, people who combined a GLP-1 medication with supervised exercise were more likely to maintain at least 10% weight loss one year after stopping treatment compared with those who used medication alone

These include tooth decay, sensitivity, enamel erosion, dry mouth, inflamed gums, and in more serious cases, cracked or loose teeth

Research also highlights concerns about oral semaglutide being less effective for weight reduction than the approved dose of injectable semaglutide