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4.5 Pregnancy and maternal-fetal outcomes: limited evidence and risk communication priorities Periconception safety should be framed as an evidence-limited risk-management problem rather than as evidence of safety

[DOI] [PubMed] [Google Scholar] 94.U

In 2020, the US Food and Drug Administration approved setmelanotide for the treatment of obesity in adults and children aged 6 years and older with monogenic obesity due to Pro-opiomelanocortin, proprotein convertase subtilisin/kexin type 1, or leptin receptor deficiency [58]

Kim, Lee, Kim, Cheon, and Lim: Successful rapid weight reduction and the use of liraglutide for morbid obesity in adolescent Prader-Willi syndrome Abstract Prader-Willi syndrome (PWS), an imprinting disorder, results from the loss of expression of a paternal gene on chromosome 15q11-q13

(13) Additionally, GLP-1 signaling may help suppress pro-inflammatory pathways, reducing the chronic low-grade inflammation associated with both obesity and bone loss

To view or add a comment, sign in Topline Phase 3 results from the SYNCHRONIZE-1 trial demonstrate that survodutide, a glucagon/GLP-1 dual agonist licensed from Zealand Pharma, achieved 16.6% average weight loss after 76 weeks
