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Kim TH, et al

Effect of Metformin Therapy on Vitamin D and Vitamin B(1)(2) Levels in Patients With Type 2 Diabetes Mellitus

If a subject is on a full replacement dose of TRT, their natural production is already suppressed
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However, as demonstrated in that same report, concomitant administration of exendin9-39 and a DPP-4 inhibitor increased food intake by 20%, suggesting that GLP-1, when potentially acting in concert with other gut hormones, might have an important role in the metabolic benefits achieved by bariatric surgery [224]

Weight loss from this medication tends to be gradual and sustained when combined with lifestyle modifications
