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And never adjust doses without medical guidance

This is one reason many endocrinologists prefer injectable GLP-1 medications for patients on thyroid hormone replacement

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They help manage hunger, improve satiety and fullness, improve insulin sensitivity and aid in healthy weight loss, along with providing both heart and kidney protection

While there is no definitively established direct mechanism by which GLP-1 receptor agonists cause fatigue, several biological pathways warrant consideration

Possibly better effects on fat metabolism (though research is ongoing) thanks to GIPs involvement