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Cholelithiasis was reported in 1 patient treated with exenatide

However, the SURMOUNT-5 trial compared tirzepatide to semaglutide 2.4mg (a more potent GLP-1 agonist than liraglutide), and tirzepatide still showed superior weight loss: 20.2% vs 13.7% at 72 weeks

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Autocrine interleukin-10 mediates glucagon-like peptide-1 receptor-induced spinal microglial -endorphin expression
How GLP-1 Medications Affect Surgical Risk Factors Semaglutide works by slowing gastric motilitythe speed at which your stomach pushes food into the small intestinewhich is essential for appetite control but poses a surgical complication risk

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