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Government programs such as Medicare and Medicaid also often have restrictions and may not cover weight-loss medication unless used for an approved condition, like OSA

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It is a virtuous cycle that directly reverses the vicious cycle of steroids causing weight gain causing more inflammation causing higher steroid doses

But the general principle applies: the more aggressive the weight loss, the more likely short-term fatigue during adaptation

Peer review Peer review information Nature Medicine thanks Javier Gmez-Ambrosi, Henrick Imberg, Tania P

I AM ON THE SECOND WEEK OF THE 10MG PER WEEK DOSE AND I HAVE MANAGED TO LOSE 28 POUNDS IN 3.5 MONTHS, WITH ALMOST NO SIDE EFFECTS