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Diabetes Care 2022;45(Suppl 1):S97S112

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While many people regain weight, those who combine gradual dose reduction, structured nutrition, regular exercise, sleep optimization, and stress management maintain 5070% of their weight loss long-term

Metformin has been reported to protect human islets against lipotoxicity 16

P 10 g daily over weeks are effective but should start gradually (e.g., 2-5 g increments) to minimize bloating or gas

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