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Figure 32: Head of the Gila monster ( Heloderma suspectum ), credit: Jeff Servoss, Wikipedia

Keywords: discontinuation syndrome, drug interactions, pharmacovigilance, psychiatric disorders, regulatory perspectives, safety concerns, serotonin syndrome, ssris Introduction and background Historical development and mechanistic foundation Selective serotonin reuptake inhibitors (SSRIs) emerged in the late 20th century as a major advancement in managing depression and other mental health conditions, developed specifically as safer alternatives to tricyclic antidepressants (TCAs) and monoamine oxidase inhibitors (MAOIs)

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It also explores the identification of the receptor and post-receptor signaling events that mediate adiponectins cardiovascular actions, along with discussions on strategies for drug discovery targeting adiponectin to treat obesity, diabetes, and CVD

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