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Non-peptide, once-per-day oral orforglipron to compete with established peptide-based, injectable GLP-1 receptor agonists

Compared with nonusers, adults taking GLP-1s had a: 17 percent lower risk of venous thromboembolism, or blood clots in the veins 31 percent lower risk of pulmonary embolism, a potentially life-threatening clot that travels to the lungs 21 percent lower risk of going to the emergency department 44 percent lower risk of all-cause mortality (death from any cause) Researchers also observed lower stroke rates among GLP-1 users, although this difference didnt reach statistical significance

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Other studies were considered active for the purposes of this analysis

This is why most medications delivered through standard transdermal patches are small, lipophilic compounds such as nicotine or certain hormones