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The efficacy of tirzepatide in lowering concentrations of HbA 1c and fasting blood glucose, and lowering body weight was directly proportional to the length of follow-up duration (appendix 15)
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However, in clinical practice, the specific effects of GLP-1RA on fracture risk and osteoporosis have not been clearly defined and evidenced

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Future investigations should rigorously assess their long-term safety and economic viability across diverse populations while expanding therapeutic indications, thereby maximizing the clinical benefits for millions of patients globally
