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Co-agonist strategy Glucose-dependent insulinotropic polypeptide (GIP) and glucagon receptor (GCGR) are currently the primary targets alongside GLP-1R for combined stimulation

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More importantly, bupropion lowers the seizure threshold, and alcohol consumption increases seizure risk

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Consequently, only about 1020% of total plasma GLP-1 remains in its biologically active form, with the majority rapidly inactivated by DPP-IV [12]

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