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Another recent study showed that liraglutide can activate the GLP-1 receptor on appetite-regulating neurons in the arcuate nucleus (ARC), which may mediate its long-term weight loss effects[131]

This is in line with the fact that, although some studies have shown the presence of the GLP-1R in other parts of the heart (Wei and Mojsov, 1995

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In fact, recent clinical trials have shown that people with type 2 diabetes who have taken a dual agonist had the following markers improve significantly: body weight fasting and after-eating glucose levels insulin sensitivity total cholesterol The only GLP-1/GIP dual agonist currently on the market is tirzepatide, branded under Mounjaro