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Increased levels of NEFAs in the liver are mainly the result of: (i) stimulated lipolysis from visceral fat (hormone-sensitive lipase cannot be sufficiently downregulated)

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However, these same metabolic changes could also lead to increased energy levels, possibly making it more difficult for some patients to wind down at night

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As a result, those with endocrine system conditions are not advised to take Ozempic or Wegovy

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