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Although they are typically mild and transient, these AEs can affect adherence and limit dose titration

Additionally, Philippaert et al., 2017 found that steviol glycosides spike insulin by potentiating pancreatic beta-cell activity through TRPM5 channel stimulation, making stevia an insulin-spiking sweetener despite contributing no calories

Some people get comfortable at low doses because side effects are minimal and there is a slight appetite reduction, so they stay there for months

Trends in FDA FY2024 Inspection-Based Warning Letters, supra note 4

This suggests that the GLP-1 findings are unlikely to be an artifact of the studys design.

Elevated brain lactate levels indicate a pathophysiological shift in brain energy metabolism from oxidative phosphorylation to glycolysis as the major source of energy generation
