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Description
Non-obese diabetic mice aged 7 weeks were treated for 1 week with JD-5037, then euthanised

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Our functional and structural data suggest that receptor conformational dynamics associated with flexibility of the peptide N-terminal activation domain may be a key determinant of agonist efficacy

Conclusions GLP-1RA therapy in patients with CS and associated metabolic disorders led to significant improvements in weight, BMI, and glycemic control without worsening cortisol dynamics or liver function
