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The FDA does not review them for safety, strength, or purity the way it reviews Zepbound and Mounjaro

Some people are highly responsive to GIP activation

conducted a retrospective study of 42 women with obesity who had used GLP1RAs for six months pre-pregnancy, but with an eight-week withdrawal before pregnancy, compared with women with obesity who chose to manage their weight with diet and exercise, and found that women who had been using GLP1RAs pre-pregnancy had reduced GWG compared to the diet and exercise group [30]

Given the suspected impairment in incretin secretion or signaling, prednisone was discontinued, while octreotide LAR was maintained (as previous withdrawal had led to worsening diarrhea), and the introduction of a long-acting GLP-1 RA was considered