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Primary care physicians will likely need education and training focused on this new class of medications, given a shortage of endocrinologists and obesity medicine specialists. Lee and colleagues noted there were study limitations, such as a lack of data on prescription indication, including whether it was used off-label. However, the increase in dispensing of injectable semaglutide for weight management suggests increasing use for this indication, they wrote

Pfeffer MA, Burdmann EA, Chen CY, Cooper ME, de Zeeuw D, Eckardt KU, et al

Healthy individuals typically have Akkermansia making up 1 to 4 percent of their total gut bacteria

Here is a summary of early evidence and hypotheses for how they might work in treating ulcerative colitis

Bouret & Simerly, 2004

Theres a class of drugs that some experts argue will be even bigger and almost nobody outside of cardiology circles has heard of them