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GLP-1, however, engages the GLP-1R/ERK1/2/HDAC6 axis to modulate downstream transcriptional activity, it lowers intracellular ROS, reduces Akt and ERK1/2 phosphorylation, restores HDAC6 expression, and thereby alleviates endothelial dysfunction and excessive autophagy (Zummo et al., 2017)
The result is a massively reduced appetite
doi: 10.1016/j.yjmcc.2020.11.014, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 66
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What Are GLP-1 Injection Site Reactions
