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Pain 152 , 11921200 (2011)
When working with athletes or individuals with higher muscle mass, Rhodes also recommends indirect calorimetry testing so we can precisely measure their resting metabolic rate or RMR to better estimate how much nutrition their body needs once we multiply this by an activity factor. This tailored approach is important because often an athletes metabolism will be very different than what is calculated using our standardized equations, as these do not consider muscle mass or an individuals metabolic efficiency. Side effects can also be problematic, with some of the most common being gastrointestinal nausea, heartburn, and constipation

If you want to dig deeper, every trial links to its ClinicalTrials.gov record in the Sources section
Always check with a healthcare professional before taking any new medications

However, lifestyle changes alone will not work for everyone to achieve their goals