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Furthermore, pharmacological activation of AMPK enhances intestinal barrier function and epithelial differentiation by promoting the key transcription factor, caudal type homeobox two (CDX2), committing cells to intestinal epithelial lineage [96]

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De primaire maatstaf voor de werkzaamheid in deze onderzoeken is het percentage gewichtsverlies, wat een robuuste indicator is voor de therapeutische kracht van het geneesmiddel

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