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As amylin and GLP-1 target different populations of neurons in the DVC 20 , this suggests that combination drug therapies affecting both systems may provide a greater magnitude and sustainable degree of weight loss compared to monotherapies due to a reduced likelihood of tachyphylaxis 21,22,23

Lee JG, Woo YS, Park SW, Seog DH, Seo MK, Bahk WM

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Cardiologists prescribing GLP-1 for cardiovascular indication patients adds an entirely new prescriber base to what was previously an endocrinology and primary care domain

Gomez-Peralta F, Abreu C, Gomez-Rodriguez S, Barranco RJ, Umpierrez GE

A few small clinical studies and observational reports indicate that individuals treated with GLP1 RAs may report reduced alcohol cravings and lower consumption levels