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N Engl J Med 2021;384:9891002.ArticlePubMed 18

This is thought to be due to the increase in inflammation that can occur, as well as elevated levels of oxidation in the body

Moreover, other studies reported that the GLP-1R signaling pathway is anti-inflammatory via regulation of NF-B signaling and subsequent promotion of cellular function in different cells, including pancreatic -cells, macrophages, and endothelial cells 52,53,54,55

Drugs Developed to Treat Diabetes, Liraglutide and Lixisenatide, Cross the Blood Brain Barrier and Enhance Neurogenesis

Pal K, Melcher K, Xu HE