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By improving overall metabolic health, reducing excess adiposity, and alleviating adipose tissue inflammation, tirzepatide could potentially mitigate upper airway collapsibility and ameliorate the underlying pathophysiological mechanisms of OSAS (27)

The reduced caloric deficit (300-500 calories versus 800 calories with higher doses) results in more gradual but sustainable weight management

Arterioscler Thromb Vasc Biol 40: 145158, 2020

Novel dual and triple agonists targeting GLP-1, GIP, Glucagon, and GDF15 for type 2 diabetes and obesity management