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Development of long-acting glucagon receptor mono-agonists 3.1
In a post hoc analysis of the SURPASS-1 trial involving patients with T2DM, the percentage increase in adiponectin levels from baseline ranged from 16% to 23% with tirzepatide compared to a decrease of 0.2% with placebo at week 40 (190)
GLP-1s are providing better weight-loss outcomes than the previous AOMs
Relative abundance of Lactobacillaceae, Bifidobacteriaceae, and Ruminococcaceae was most affected by DSS stimulation, but GLP-1 treatment helped Lactobacillaceae, Bifidobacteriaceae to survive and flourish
[8] Rybelsus (semaglutide) [prescribing information]
Consequently, the expression of secretory lineage markers is dramatically reduced
