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Description
Mitochondrial dysfunction in depression
Hyperglycemia and IR have been linked to increased -synuclein aggregation, further implicating the role of diabetes in the pathogenesis of PD [22]

methodology, O.F

By mimicking the effects of GLP-1, a hormone that regulates appetite and blood sugar, semaglutide helps reduce hunger and support long-term weight management

GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism

Important Limitation SURPASS-2 compared tirzepatide against semaglutide 1mg (the Ozempic dose for diabetes), not the higher 2.4mg dose used for weight loss (Wegovy)
