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While studies on initial combination therapy have not yet directly demonstrated a reduction in long-term complications, the well-established benefits of tight glycemic control suggest that early combination therapy may contribute to lower complication rates in the future

doi: 10.1016/j.ejphar.2021.174310 47 HansenDVHansonJEShengM

Thats a genuinely interesting mechanistic story

Its kind of like an amuse bouche happening in your mouth. Too much acid overpowers other flavors and can also upset even the strongest constitutions

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Roche said Vabysmo showed a high uptake among both newly diagnosed patients as well as patients transitioning from other treatment options