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Secondly, retatrutide may have released cardiac noradrenaline in the heart to raise the beating rate through cardiac -adrenoceptors

Lastly, the wider CrIs in the NMA compared with the CI in SURMOUNT-5 may be explained by the use of a Bayesian analysis with random effect for the NMA, resulting in greater uncertainty in the results introduced by the heterogeneity of multiple trials per treatment comparison in the NMA

Most patients begin at microdose levels and advance to standard therapeutic ranges based on their tolerance and weight-loss progress

& Samayoa, G

These patients should discuss whether tirzepatide is appropriate given their history
