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doi: 10.2337/diabetes.51.5.1299 248

Two different selenium-dependent iodothyronine deiodinases (DIOs type 1 and 2) can deiodinate T 4 , thus increasing circulating T 3 , while a third iodothyronine deiodinase (DIO type 3) can convert both T 3 and T 4 to inactive metabolites ( Figure 3 ) (10, 11)

Scheller U., Lee C., Seibler P., et al., Impaired Neurogenesis and Synaptogenesis in iPSCderived Parkinson's Patient Cortical Neurons With D620N VPS35 Mutation, BioRxiv (2024), 10.1101/2024.08.07.606995

RESULTS The AnglV analog D~Nle-Tyr-Ile-NH-(CH 2 ) 5-CONH2 is more metabolically stable than Norleual (Nle-Tyr-Leu^-(CH 2 -NH 2 f- 4 -His-Pro~Phe (SEQ ID NO: 1) The AnglV-related peptidomimetic Norleual was previously shown to possess, anti- HGF/Met, anti-angiogenic, and anti-cancer activities

Lower inflammation can also contribute to improved joint mobility and function

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