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In a Phase 2a substudy published in Nature Medicine, retatrutide at the 12mg dose reduced liver fat by an average of 82.4% from baseline at 24 weeks

However, theres an important caveat: 5-HTP affects serotonin levels, so it can interact with medications that also affect serotonin (such as SSRIs and MAOIs)

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Although these adverse events are generally similar to those seen with injectable formulations, they can become more prominent during dose escalation and titration periods

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