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10.1016/j.pharmthera.2022.108119 Pharmacol

Weight loss doseeffect analyses were performed according to the magnitude of body weight change during the trial confined to the semaglutide group, because the primary objective was to examine the effects of body weight change related to semaglutide treatment rather than spontaneous or other lifestyle-related weight changes (as in the placebo group), using both intention-to-treat (primary) and on-treatment approaches

Due to the induction of a nutrient deprivation state, SGLT2 inhibitors upregulate the energy deprivation sensor AMPK (23) and its immunoregulatory effects ( Figure 1 )

Rhett noted that many of these improvements reflect better eating patterns rather than the medication alone
