glp-1 and glp-2 Discovery, characterization, clinical development of the glucagon-like peptides GLP-1 & GLP-2

Description

Going lower risks metabolic adaptation, where your body downregulates metabolism to match the reduced intake, creating the plateau that frustrates so many GLP-1 users

Cell 80 , 485500 (2020)

Elisabet Jerlhag, from the Department of Pharmacology at the Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, explained to Medical News Today : We found that semaglutide, given once or at several occasions, reduces alcohol intake in male and female rats

An uncontrolled UK-based study found that optimising glycaemic control with continuous subcutaneous insulin infusions in people with diabetic gastroparesis resulted in substantial reductions in hospitalisation, although this requires corroboration in other trials