dulaglutide to semaglutide conversion GLP-1 receptor agonists in the treatment of type 2 diabetes – state-of-the-art Switching from Semaglutide to Tirzepatide:
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Different stimuli cause ERK1/2 activity to different degrees, intracellular compartmentalization, and durations, suggesting that these effects are unique [41]

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Of note, the role as loss of -arrestin-1 does not affect GLP-1R internalization on the other hand, enhancing -arrestin-2 action by the overexpression of G protein receptor kinase 5 (GRK5) increases GLP-1R endocytosis [53]
