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1 Monitor renal function and CrCl for all GLP-1 RAs

Meanwhile, Glucagon-like peptide 1 receptor agonists attenuate autophagy via Drp1/NOX- and Atg-5/Atg-7/Beclin-1/LC3 pathways to improve pulmonary hypertension [55]

(vii) reduce the production/secretion of tumor necrosis factor alpha (TNF-), interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1/CCL2), plasminogen activator inhibitor type 1 (PAI-1), transforming growth factor beta-1 (TGF-1) and angiotensinogen, while it can stimulate the secretion/activity of adiponectin

GLP-1RAs exert glycemic control through multiple mechanisms, including the stimulation of insulin secretion under hyperglycemic conditions, suppression of glucagon secretion during hyperglycemia, deceleration of gastric emptying to mitigate postprandial glucose spikes, reduction of caloric intake, and promotion of weight loss.71,8183 Short-acting GLP-1RAs, such as exenatide and lixisenatide, primarily reduce nocturnal and fasting glucose levels, while maintaining their effect on gastric emptying over prolonged treatment periods

Ozempic - A weekly injection used to manage type 2 diabetes

So lets say, for example, from a clinical perspective, if a patient in front of us in clinic, how do we determine where we start