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Am J Physiol Endocrinol Metab 314: E572E583

Option 3: Accept a lower maintenance dose If 12mg is persistently intolerable after repeated attempts, 8mg is a clinically reasonable maintenance dose

5, May 2019, pp

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[1] [2] Based on pharmacological principles, it typically takes five half-lives for a medication to be considered essentially eliminated from the body (approximately 97% cleared)

The standard oral dose for weight management is 1,000-2,000 mg daily, typically split into two doses taken with meals