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Physicians generally prefer once-daily pills over twice-daily drugs, Wells Fargo analyst Mohit Bansal said in a research note in June

Recalls & Warnings November 29, 2023 Dr

In a study on Qsymia, people lost up to 10% of their starting body weight after 13 months

Insulin resistance plays an important role in the pathophysiology of comorbid T2DM and depression and can be a trigger for dysregulation of insulin- and GLP-1-mediated signaling (both central and peripheral), neuroendocrine disorders (hypothalamicpituitaryadrenal system dysfunction and monoaminergic neurotransmission disorders), chronic low-intensity inflammation, oxidative stress, and disorders of the microbiota-gut-brain system, reducing the level of neurotrophic factors in the brain and changing synaptic plasticity

Whether these next-generation compounds will offer even broader non-weight-loss benefits remains an active area of investigation

doi: 10.1056/nejmoa2302392