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The most substantial weight reduction in the phase 2 trial was observed from weeks 12 onwards , during which participants were approaching or at their target dose

In fact, some people report mood changes on the drug

The cardiovascular phenomenon of endothelial dysfunction involves a series of structural and functional abnormalities, including abnormal secretory capacity and properties of the endothelium and impaired vascular tone, as well as an impaired endothelial barrier function