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Insulin-sensitizing drugs are the second-line treatment, with metformin being the most recommended therapeutic option, to improve peripheral insulin sensitivity in order to decrease insulin levels and, consequently, insulin-mediated stimulation of ovarian androgen secretion 17

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[DOI] [PMC free article] [PubMed] [Google Scholar] 33.Moody AJ, Holst JJ, Thim L, Jensen SL