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GLP-1 (Glucagon-like peptide-1) plays a crucial role in managing blood sugar levels, reducing appetite, and supporting weight loss by influencing insulin and glucagon production.

Method We systematically searched PubMed and Embase from inception to 1 May 2025 for cohort studies comparing the effect of combination therapy with SGLT2 inhibitor or GLP-1 RA monotherapy on (cardiovascular) mortality and cardiovascular or kidney endpoints in individuals with type 2 diabetes