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The locus coeruleus contributes to the anorectic, nausea, and autonomic physiological effects of glucagon-like peptide-1

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Sublingual dosing offers an alternative route of administration by allowing absorption directly into the bloodstream through the mucosal tissue, bypassing the gastrointestinal system and first-pass metabolism

Furthermore, evidence has shown that once-weekly versus once-daily administration of subcutaneous GLP-1RAs led to improvements in treatment persistence and adherence [10]

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