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13 The efficacy in these studies is akin to what we have observed following treatment with exenatide for 3 months (5.6 cmCSF)
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Gastrointestinal adverse events (nausea, vomiting, constipation, diarrhea) scale with dose in the STEP program, and about 4.5% of patients discontinue for GI reasons on 2.4 mg semaglutide (Wilding et al., NEJM 2021)
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