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Development of a fluorescence-based assay for drug interactions with human Multidrug Resistance Related Protein (MRP2

Since the benefits of tight glycaemic control early in the disease are well documented, and sustained weight loss is recognised as an important goal in those with obesity and type 2 diabetes, the authors argue that guidelines may need to change to harness the potential benefits of tirzepatide, other incretin co-agonists and other combination drugs in development

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The 23 month window accounts not only for drug clearance but also for endocrine rebalancing, menstrual cycle normalization, and resolution of nausea or gastrointestinal effects that might complicate early pregnancy

and avoiding high-fat or spicy foods during the initial adjustment period significantly reduces symptom severity