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This dual mechanism (direct and secondary) likely contributes to the overall motility dysfunction observed with GLP-1 RA therapy, which can result in bowel obstruction, particularly in individuals with preexisting motility issues

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The SURPASS-3MRI trial, which is a subsidiary study of the phase 3 SURPASS-3 trial, explored the effects of tirzepatide exhibited a notable decrease in liver fat content in comparison to insulin degludec (8.09% vs

Wang F, et al