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However, recent insights suggest that the gut and brain GLP-1 systems operate largely independently with mRNA transcripts for proglucagon (GCG), the precursor peptide for GLP-1, being abundant in the brainstem, particularly within the nucleus tractus solitarius (NTS

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BMT itself increased plasma active GLP-1 levels in control animals (Supplemental Figure 2, B and D)

February 1, 2025

1B ), but not in WD-fed subjects ( p = 0.598)
