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In conclusion, MNs/GLP-1RAs@NPs-WYRGRL can serve as an efficient drug delivery system to achieve sustained GLP-1RAs release at the disease site and prolong the drug effect
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Histological analysis revealed that mice treated with HORN-MN exhibited increased UCP1 protein expression in iWAT, along with reduced adipocyte size, indicating successful browning of white adipocytes
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The cormorbidities often associated with HFpEF such as obesity, diabetes mellitus, and hypertension as well as the metabolic changes associated with them are known to induce a state of inflammation that affects cardiac metabolism, as well as coronary vascular injury and ischemia [5]
Insulin-like peptide 5 is an orexigenic gastrointestinal hormone
