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Whereas previous research has demonstrated the feasibility of using peptides to target nuclear hormone receptors 46,47 , to our knowledge, this is the first single molecule that uses a G-protein-coupled-receptor targeting approach to deliver a small-molecule modulator of an ionotropic receptor

The dysregulation of intracellular calcium in Alzheimers disease

Lastly, using in vivo calcium imaging we showed that the efficacy of systemic exendin-4 is associated with dynamic changes in activity of VTA GABA and dopamine neurons that are associated with decreased cocaine seeking

Until more research is available, the use of these drugs in T1D should be done carefully, with a thorough discussion with patients about potential risks and benefits of this approach

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