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In STEP-1 (Wilding et al., NEJM 2021), 68 weeks of once-weekly 2.4 mg semaglutide plus lifestyle intervention produced a mean body-weight reduction of about 15%, versus about 2.4% with placebo a large, clinically meaningful, well-replicated effect

Estimated lifetime cardiovascular, kidney, and mortality benefits of combination treatment with SGLT2 inhibitors, GLP-1 receptor agonists, and nonsteroidal mra compared with conventional care in patients with type 2 diabetes and albuminuria

doi: 10.1016/j.cjtee.2022.06.002 8

This approach is oftentimes an important complement to surgery for patients experiencing significant midface deflation due to GLP-1 agonists, he said, as it allows for effective mobilization and resuspension of midface volume. Combining fat transfer with lifting techniques is also important for restoring natural contours and avoiding the hollow or skeletonized look that can happen with a lift alone, said Ramesh

Instead, pick light, simple options with neutral flavors like a turkey sandwich or soup