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Her experience shows that while responses to GLP-1 medications can vary, some individuals find them highly effective and easy to tolerate for managing PCOS-related weight challenges

ASCVD, atherosclerotic cardiovascular disease

Tirzepatide has an obviously lower affinity with GIPR than GIP does (pIC 50 : 6.70 vs 7.87), and its cAMP activity is approximately equal to that of GIP

Even short-acting compounds like Ex4 exhibit limited penetration, and their CNS effects may depend on indirect mechanisms such as vagal afferent activation or diffusion via tanycytic transport from cerebrospinal fluid

The downsides of GLP-1s can be summed up in one message: You dont know what youre getting

Classical examples include thalidomide and aspirin, where toxicity profiles diverged significantly between rodents and humans